2 edition of Benzo[a]pyrene metabolism in the American oyster, Crassostrea virginica found in the catalog.
Benzo[a]pyrene metabolism in the American oyster, Crassostrea virginica
Robert S. Anderson
by Environmental Research Laboratory, Office of Research and Development, U. S. Environmental Protection Agency, Available to the public through the National Technical Information Service in Gulf Breeze, Fla, Springfield, Va
Written in English
|Statement||by Robert S. Anderson.|
|Series||Ecological research series -- EPA-600/3-78-009., Research reporting series -- EPA-600/3-78-009.|
|Contributions||Environmental Research Laboratory (Gulf Breeze, Fla.).|
|The Physical Object|
|Pagination||v, 18 p. :|
|Number of Pages||18|
Relationship between metabolism and bioaccumulation of benzo[α]pyrene in benthic invertebrates † Aaron J. Rust Marine Sciences Research Center, Stony Brook University, Stony Brook, New York –, USACited by: The eastern oyster (Crassostrea virginica) developed neoplastic disorders when experimentally exposed both in the laboratory and field to chemically contaminated sediment from Black Rock Harbor (BRH), Bridgeport, Connecticut. Benzo(a)pyrene Metabolism in the American Oyster Crassostrea virginica.
Benzo(a)pyrene (BAP) and dibenzo(a,h)anthracene (DBA) are both carcinogenic PAHs found in environmental samples, specifically oysters (Crassostrea virginica) collected from Galveston Bay. Dose-response studies more» were conducted with H4IIE cells to determine the relative induction potency of these two PAHs relative to 2,3,7,8-TCDD. The genotoxic mechanism of action of benzo[a]pyrene involves metabolism to highly reactive species that form covalent adducts to DNA. These anti-benzo[a]pyrene-7,8-diol- 9,oxide-DNA adducts induce mutations in the K-RAS oncogene and the TP53 tumorsuppressor gene in human lung tumors, and in corresponding genes in mouse-lung tumors.
PAHs include fluoranthene, benzo[a]pyrene (BaP), pyrene, and chrysene (Bieri et al. ; Vogelbein et al. ). The sediment is acutely toxic and highly teratogenic to a variety of spe-cies of aquatic organisms including American oysters (Crassostrea virginica), brackish water clams (Rangia cuneata), and fish such as spot. Benzo[a]pyrene is a polycyclic aromatic hydrocarbon and the result of incomplete combustion of organic matter at temperatures between °C ( °F) and °C (1, °F).The ubiquitous compound can be found in coal tar, tobacco smoke and many foods, especially grilled meats. The substance with the formula C 20 H 12 is one of the benzopyrenes, formed by a benzene ring fused to al formula: C₂₀H₁₂.
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BENZO[a]PYRENE METABOLISM IN THE Benzo[a]pyrene metabolism in the American oyster OYSTER CRASSOSTREA VIRGINICA by Robert S. Anderson Sloan-Kettering Institute for Cancer Research Donald S. Walker Laboratory Rye, New York Grant No.
R Project Officer John A. Couch Environmental Research Laboratory U.S. Environmental Protection Agency Gulf Breeze, Florida Environmental Research.
Benzo[a]pyrene metabolism in the American oyster, Crassostrea virginica. Gulf Breeze, Fla.: Environmental Research Laboratory, Office of Research and Development, U.S.
Crassostrea virginica book Protection Agency ; Springfield, Va.: Available to the public through the National Technical Information Service, (OCoLC) Material Type. The sediment is acutely toxic and highly teratogenic to a variety of species of aquatic organisms including American oysters (Crassostrea virginica), brackish water clams Varanasi U, Nishimoto M, Reichert WL, Le Eberhart BT.
Comparative metabolism of benzo(a)pyrene and covalent binding to hepatic DNA in English sole, starry flounder Cited by: Using a sensitive, radioisotopic assay for aryl hydrocarbon hydroxylase (AHH), a comparatively low level of benzo(a)pyrene (BaP) metabolism was routinely measured in digestive gland homogenates.
Attempts to induce overall BaP metabolism by exposure to Arocloran inducer of mammalian AHH, were largely by: 5. The levels of these components and rates of microsomal benzo[a]pyrene (BP) metabolism were highest in the digestive gland, and were very similar between species.
In M. edulis there was a suggested seasonal variation in BP metabolism but no population differences in this activity or in levels of other components. Digestive gland microsomal Cited by: High-performance liquid chromatographic analysis showed that P 1B1 catalyzed benzo[a]pyrene to trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene at level of ∼3 nmol min-1 nmol of P only when epoxide hydrolase was present and P 1A1 (with the hydrolase) was able to catalyze benzo[a]pyrene at one-tenth of the activity catalyzed by P 1B1.
Benzo[a]pyrene metabolism. Benzo[a]pyrene is a procarcinogen produced during incomplete combustion of organic compounds such as oil, gasoline and charbroiled food.
The mechanism of carcinogenesis of Benzo[a]pyrene is defined by its enzymatic conversion to the ultimate mutagen, Benzo[a]pyrene diol epoxide (BPDE,).This molecule intercalates in DNA by forming covalent bond. Benzo[a]pyrene (B[a]P), a representative polycyclic aromatic hydrocarbon (PAH), is metabolically activated by three enzymatic pathways; by peroxidases (e.g.
cytochrome Pperoxidase) to yield radical cations; by PA1/1B1 monoxygenation plus epoxide hydrolase to yield diol-epoxides; and by PA1/1B1 monoxygenation, epoxide hydrolase plus aldo-keto reductases (AKRs) to yield o Cited by: Fortner AR, Sick LV () Simultaneous accumulations of naphthalene, a PCB mixture, and benzo(a)pyrene, by the oyster, Crassostrea virginica.
Bull Environ Contam Toxicol – Bull Environ Contam Toxicol –Cited by: I also acknowledge Dr. John Vernberg for his valuable guidance. This article is contribution number from the Belle W. Baruch Institute for Marine Biology and Coastal Ecology. References Anderson R. () Benzo(a)pyrene metabolism in the American oyster, Crassostrea by: 7.
Metabolism of a carcinogen by biralre molluscs TABLE 2 High-Performance Liquid Chromatography of `1C-BP Metabolites Produced by Bivalve Digestive Gland Homogenates (cpm, 45 min) Mercenaria mercenaria Crassostrea virginica Control Aroclor Aroclor Control Aroclor Aroclor (25Omg) ( mg) (25Omg)( mg) 9, l0-diol 48 4,5-diol Cited by: Request PDF | Transcriptomic evaluation of the American oyster, Crassostrea virginica, deployed during the Deepwater Horizon oil spill: Evidence of an active hydrocarbon response pathway.
Bioremediation and microbial metabolism of benzo(a)pyrene. Erin M. Ostrem Loss. This review intends to compare what is known about bacterial and fungal degradation of toxic compounds using benzo(a)pyrene as a relevant example.
Most research is done in the context of using fungi for bioremediation, however, we intend to also point out how Cited by: 6.
Environmental Health Perspectives is an Open Access journal published by the National Institute of Environmental Health Sciences. The sediment is acutely toxic and highly teratogenic to a variety of species of aquatic organisms including American oysters (Crassostrea virginica), Comparative metabolism of benzo(a)pyrene and covalent Cited by: We investigated the metabolism of the carcinogen benzo[a]pyrene (BaP) by liver microsomes of channel catfish (Ictalurus punctatus) and brown bullhead (Ameiurus nebulosus) pretreated with 3‐ catfish liver microsomes metabolized BaP at a considerably lower rate than did the brown bullhead liver by: 7.
The American oyster Crassostrea virginica, an ecologically and economically important estuarine organism, can suffer high mortalities in areas in the Northeast United States due to Roseovarius. Toxicological Review of Benzo[a]pyrene [CASRN ] January Integrated Risk Information System.
National Center for Environmental Assessment. Office of Research and Development. U.S. Environmental Protection Agency. Washington, DC. Metabolism of Benzo(a)pyrene. The overall metabolism of l"C]-benzo(a)pyrene was determined using an extraction assay (10) or by summing the amounts of the individual metabolites detected by high-pressure liquid chromatography.
High-pressure liquid chromatography was performed as described previously (4), except that the acetone. The metabolism of benzo(a)pyrene by human liver mi crosomes and human lymphocytes has been analyzed by high-pressure liquid chromatography.
Human liver forms seven known metabolites and at least five additional unidentified metabolites that migrate as distinct peaks. Lymphocytes incubated with benzo(a)pyrene for 30 mm do not form dihydrodiols. Regarding cell metabolism, we have shown previously, in rat epithelial hepatic F cells, that B[a]P can affect lipid metabolism 14 and the expression of Cited by:.
Polycyclic aromatic hydrocarbons (Benzo[a]pyrene) Toxicological Overview Key Points Kinetics and metabolism PAHs are absorbed by all routes of exposure PAHs are distributed widely throughout the body, with fatty tissues tending to show higher amounts.Jiang H, Gelhaus SL, Mangal D, Harvey RG, Blair IA, Penning TM; ''Metabolism of benzo[a]pyrene in human bronchoalveolar H cells using liquid chromatography-mass spectrometry.''; Chem Res Toxicol, PubMed Europe PMC.Benzo(a)pyrene metabolism in the American oyster, Crassostrea virginica / (Gulf Breeze, Fla.: Environmental Research Laboratory, Office of Research and Development, U.
S. Environmental Protection Agency ; Springfield, Va.: Available to the public through the National Technical Information Service, ), by Robert S. Anderson and Fla.